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1

Frontiers proposal. National Institute on Aging “bench to bedside: estrogen as a case study”

Sanjay Asthana, Roberta Diaz Brinton, Victor W. Henderson, Bruce S. McEwen, John H. Morrison, Peter J. Schmidt, for the Frontiers Proposal for Estrogen and Cognitive Aging Work Groups

Journal:

Year:

2009

Language:

english

File:

PDF, 214 KB

english, 2009

2

Progesterone receptors: Form and function in brain

Roberta Diaz Brinton, Richard F. Thompson, Michael R. Foy, Michel Baudry, JunMing Wang, Caleb E. Finch, Todd E. Morgan, Christian J. Pike, Wendy J. Mack, Frank Z. Stanczyk, Jon Nilsen

Journal:

Frontiers in Neuroendocrinology

Year:

2008

Language:

english

File:

PDF, 1.11 MB

english, 2008

3

Equilin, a Principal Component of the Estrogen Replacement Therapy Premarin, Increases the Growth of Cortical Neurons via an NMDA Receptor-Dependent Mechanism

Roberta Diaz Brinton, Pam Proffitt, Julie Tran, Richard Luu

Journal:

Experimental Neurology

Year:

1997

Language:

english

File:

PDF, 360 KB

english, 1997

4

Impact of Type 2 Diabetes and Postmenopausal Hormone Therapy on Incidence of Cognitive Impairment in Older Women

Espeland, Mark A., Brinton, Roberta Diaz, Hugenschmidt, Christina, Manson, JoAnn E., Craft, Suzanne, Yaffe, Kristine, Weitlauf, Julie, Vaughan, Leslie, Johnson, Karen C., Padula, Claudia B., Jackson,

Journal:

Year:

2015

Language:

english

File:

PDF, 806 KB

english, 2015

5

Age, APOE and Sex: Triad of Risk of Alzheimer's Disease

Riedel, Brandalyn C., Thompson, Paul M., Brinton, Roberta Diaz

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2016

Language:

english

File:

PDF, 1.24 MB

english, 2016

6

How would we combat menopause as an Alzheimer’s risk factor?

Mosconi, Lisa, Brinton, Roberta Diaz

Journal:

Expert Review of Neurotherapeutics

Year:

2018

Language:

english

File:

PDF, 565 KB

english, 2018

7

Association of combination statin and antihypertensive therapy with reduced Alzheimerâs disease and related dementia risk

Barthold, Douglas, Joyce, Geoffrey, Diaz Brinton, Roberta, Wharton, Whitney, Kehoe, Patrick Gavin, Zissimopoulos, Julie, Rajji, Tarek K.

Journal:

Year:

2020

File:

PDF, 640 KB

2020

8

Selective estrogen receptor modulators (SERM) for the brain: Recent advances and remaining challenges for developing a NeuroSERM™

Roberta Diaz Brinton

Journal:

Drug Development Research

Year:

2002

Language:

english

File:

PDF, 188 KB

english, 2002

9

Estrogen receptor β as a therapeutic target for promoting neurogenesis and preventing neurodegeneration

Liqin Zhao, Roberta Diaz Brinton

Journal:

Drug Development Research

Year:

2005

Language:

english

File:

PDF, 543 KB

english, 2005

10

Vasopressin induction of long-lasting potentiation of synaptic transmission in the dentate gyrus

Chong Chen, Roberta Díaz Brinton, Tracey J. Shors, Richard F. Thompson

Journal:

Year:

1993

Language:

english

File:

PDF, 1.07 MB

english, 1993

11

Vasopressin-induced neurotrophism in cultured hippocampal neurons via V1 receptor activation

Roberta Diaz Brinton, Alex W. Monreal, Judivick G. Fernandez

Journal:

Developmental Neurobiology

Year:

1994

Language:

english

File:

PDF, 1.29 MB

english, 1994

12

Investigative Models for Determining Hormone Therapy-Induced Outcomes in Brain: Evidence in Support of a Healthy Cell Bias of Estrogen Action

ROBERTA DIAZ BRINTON

Journal:

Annals of the New York Academy of Sciences

Year:

2005

Language:

english

File:

PDF, 23.17 MB

english, 2005

13

Advances and Challenges in the Prevention and Treatment of Alzheimer's Disease

Roberta Diaz Brinton, Rose S. Yamazaki

Journal:

Pharmaceutical Research

Year:

1998

File:

PDF, 1.64 MB

1998

14

17 β-Estradiol Enhances the Outgrowth and Survival of Neocortical Neurons in Culture

Roberta Diaz Brinton, Julie Tran, Pam Proffitt, Maria Montoya

Journal:

Neurochemical Research

Year:

1997

Language:

english

File:

PDF, 1.12 MB

english, 1997

15

Vasopressin-induced calcium signaling in cultured hippocampal neurons

Roberta Diaz Brinton, Tania M. Gonzalez, Wing S. Cheung

Journal:

Year:

1994

Language:

english

File:

PDF, 622 KB

english, 1994

16

Vasopressin-induced calcium signaling in cultured hippocampal neurons

Roberta Diaz Brinton, Tania M. Gonzalez, Wing S. Cheung

Journal:

Year:

1994

Language:

english

File:

PDF, 894 KB

english, 1994

17

Estrogen regulation of glucose metabolism and mitochondrial function: Therapeutic implications for prevention of Alzheimer's disease

Roberta Diaz Brinton

Journal:

Advanced Drug Delivery Reviews

Year:

2008

Language:

english

File:

PDF, 392 KB

english, 2008

18

Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons

Liqin Zhao, Tzu-wei Wu, Roberta Diaz Brinton

Journal:

Year:

2004

Language:

english

File:

PDF, 460 KB

english, 2004

19

Estrogen receptor α and β differentially regulate intracellular Ca2+ dynamics leading to ERK phosphorylation and estrogen neuroprotection in hippocampal neurons

Liqin Zhao, Roberta Diaz Brinton

Journal:

Year:

2007

Language:

english

File:

PDF, 857 KB

english, 2007

20

Estrogen protection against mitochondrial toxin-induced cell death in hippocampal neurons: Antagonism by progesterone

Jia Yao, Shuhua Chen, Enrique Cadenas, Roberta Diaz Brinton

Journal:

Year:

2011

Language:

english

File:

PDF, 986 KB

english, 2011

21

Hippocampal responsiveness to 17β-estradiol and equol after long-term ovariectomy: Implication for a therapeutic window of opportunity

Ryan T. Hamilton, Jamaica R. Rettberg, Zisu Mao, Jimmy To, Liqin Zhao, Susan E. Appt, Thomas C. Register, Jay R. Kaplan, Roberta Diaz Brinton

Journal:

Year:

2011

Language:

english

File:

PDF, 1.17 MB

english, 2011

22

The effect of dietary soy isoflavones before and after ovariectomy on hippocampal protein markers of mitochondrial bioenergetics and antioxidant activity in female monkeys

Jamaica R. Rettberg, Ryan T. Hamilton, Zisu Mao, Jimmy To, Liqin Zhao, Susan E. Appt, Thomas C. Register, Jay R. Kaplan, Roberta Diaz Brinton

Journal:

Year:

2011

Language:

english

File:

PDF, 1.21 MB

english, 2011

23

Regenerative potential of allopregnanolone

Jun Ming Wang, Lifei Liu, Ronald W. Irwin, Shuhua Chen, Roberta Diaz Brinton

Journal:

Brain Research Reviews

Year:

2008

Language:

english

File:

PDF, 768 KB

english, 2008

24

Dual action of estrogen on glutamate-induced calcium signaling: mechanisms requiring interaction between estrogen receptors and src/mitogen activated protein kinase pathway

Jon Nilsen, Shuhua Chen, Roberta Diaz Brinton

Journal:

Year:

2002

Language:

english

File:

PDF, 4.21 MB

english, 2002

25

Vasopressin-induced cytoplasmic and nuclear calcium signaling in cultured cortical astrocytes

Lixia Zhao, Roberta Diaz Brinton

Journal:

Year:

2002

Language:

english

File:

PDF, 2.97 MB

english, 2002

26

Vasopressin-induced calcium signaling in cultured cortical neurons

Michael C. Son, Roberta Diaz Brinton

Journal:

Year:

1998

Language:

english

File:

PDF, 484 KB

english, 1998

27

Spatial, cellular and temporal basis of vasopressin potentiation of norepinephrine-induced cAMP formation

Roberta Diaz Brinton, Richard H Thompson, Elizabeth A Brownson

Journal:

European Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 1.73 MB

english, 2000

28

Select estrogens within the complex formulation of conjugated equine estrogens (Premarin®) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease

Liqin Zhao, Diaz Roberta Brinton

Journal:

BMC Neuroscience

Year:

2006

Language:

english

File:

PDF, 842 KB

english, 2006

29

Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function

Jon Nilsen, Shuhua Chen, Ronald W Irwin, Sean Iwamoto, Diaz Roberta Brinton

Journal:

BMC Neuroscience

Year:

2006

Language:

english

File:

PDF, 1.45 MB

english, 2006

30

Allopregnanolone-induced rise in intracellular calcium in embryonic hippocampal neurons parallels their proliferative potential

Jun Ming Wang, Diaz Roberta Brinton

Journal:

BMC Neuroscience

Year:

2008

Language:

english

File:

PDF, 1.71 MB

english, 2008

31

Regulation and Mechanism of L-Type Calcium Channel Activation via V1a Vasopressin Receptor Activation in Cultured Cortical Neurons

Michael C. Son, Roberta Diaz Brinton

Journal:

Neurobiology of Learning and Memory

Year:

2001

Language:

english

File:

PDF, 2.91 MB

english, 2001

32

Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence

Jia Yao, Ryan T. Hamilton, Enrique Cadenas, Roberta Diaz Brinton

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2010

Language:

english

File:

PDF, 551 KB

english, 2010

33

Selective estrogen receptor modulators (SERMs) for the brain: Current status and remaining challenges for developing NeuroSERMs

Liqin Zhao, Kathleen O’Neill, Roberta Diaz Brinton

Journal:

Brain Research Reviews

Year:

2005

Language:

english

File:

PDF, 5.08 MB

english, 2005

34

Impact of the selective estrogen receptor modulator, raloxifene, on neuronal survival and outgrowth following toxic insults associated with aging and Alzheimer's disease

Kathleen O'Neill, Shuhua Chen, Roberta Diaz Brinton

Journal:

Experimental Neurology

Year:

2004

Language:

english

File:

PDF, 1.59 MB

english, 2004

35

Impact of the selective estrogen receptor modulator, tamoxifen, on neuronal outgrowth and survival following toxic insults associated with aging and Alzheimer's disease

Kathleen O'Neill, Shuhua Chen, Roberta Diaz Brinton

Journal:

Experimental Neurology

Year:

2004

Language:

english

File:

PDF, 322 KB

english, 2004

36

Shift in brain metabolism in late onset Alzheimer’s disease: Implications for biomarkers and therapeutic interventions

Jia Yao, Jamaica R. Rettberg, Lauren P. Klosinski, Enrique Cadenas, Roberta Diaz Brinton

Journal:

Molecular Aspects of Medicine

Year:

2011

Language:

english

File:

PDF, 556 KB

english, 2011

37

17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: Relevance to Alzheimer's prevention

Liqin Zhao, Jia Yao, Zisu Mao, Shuhua Chen, Yan Wang, Roberta Diaz Brinton

Journal:

Neurobiology of Aging

Year:

2011

Language:

english

File:

PDF, 4.21 MB

english, 2011

38

Ovarian hormone loss induces bioenergetic deficits and mitochondrial β-amyloid

Jia Yao, Ronald Irwin, Shuhua Chen, Ryan Hamilton, Enrique Cadenas, Roberta Diaz Brinton

Journal:

Neurobiology of Aging

Year:

2012

Language:

english

File:

PDF, 3.21 MB

english, 2012

39

Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice

Chanpreet Singh, Lifei Liu, Jun Ming Wang, Ronald W. Irwin, Jia Yao, Shuhua Chen, Sherry Henry, Richard F. Thompson, Roberta Diaz Brinton

Journal:

Neurobiology of Aging

Year:

2012

Language:

english

File:

PDF, 1.99 MB

english, 2012

40

The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications

Roberta Diaz Brinton

Journal:

Trends in Neurosciences

Year:

2008

Language:

english

File:

PDF, 1.27 MB

english, 2008

41

Estrogen-induced plasticity from cells to circuits: predictions for cognitive function

Roberta Diaz Brinton

Journal:

Trends in Pharmacological Sciences

Year:

2009

Language:

english

File:

PDF, 1.40 MB

english, 2009

42

Localization of V1a vasopressin receptor mRNA expression in cultured neurons, astroglia, and oligodendroglia of rat cerebral cortex

Rose S. Yamazaki, Qi Chen, Steven S. Schreiber, Roberta Diaz Brinton

Journal:

Molecular Brain Research

Year:

1997

Language:

english

File:

PDF, 504 KB

english, 1997

43

Vasopressin-induction of the immediate early gene, NGFI-A, in cultured hippocampal glial cells

Roberta Diaz Brinton, Rose Yamazaki, Claudia M. Gonzalez, Kathleen O'Neill, Steven S. Schreiber

Journal:

Molecular Brain Research

Year:

1998

Language:

english

File:

PDF, 4.80 MB

english, 1998

44

The women’s health initiative estrogen replacement therapy is neurotrophic and neuroprotective

Roberta Diaz Brinton, Shuhua Chen, Marissa Montoya, Debra Hsieh, Jasmin Minaya, Jeffrey Kim, Hsiao-Pai Chu

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 1.32 MB

english, 2000

45

The estrogen replacement therapy of the Women’s Health Initiative promotes the cellular mechanisms of memory and neuronal survival in neurons vulnerable to Alzheimer’s disease

Roberta Diaz Brinton, Shuhua Chen, Marissa Montoya, Debra Hsieh, Jasmin Minaya

Journal:

Year:

2000

Language:

english

File:

PDF, 1.61 MB

english, 2000

46

17β-Estradiol and Progesterone Regulate Expression of β-Amyloid Clearance Factors in Primary Neuron Cultures and Female Rat Brain

Jayaraman, Anusha, Carroll, Jenna C., Morgan, Todd E., Lin, Sharon, Zhao, Liqin, Arimoto, Jason M., Murphy, M. Paul, Beckett, Tina L., Finch, Caleb E., Brinton, Roberta Diaz, Pike, Christian J.

Journal:

Year:

2012

Language:

english

File:

PDF, 584 KB

english, 2012

47

Clinical progestins and their efficacy to promote neuron survival and neurogenesis

Jinxia Deng, Jon Nilsen, Roberta Diaz Brinton

Journal:

Alzheimer's & Dementia

Year:

2005

Language:

english

File:

PDF, 47 KB

english, 2005

48

Estrogen regulation of mitochondrial function: Target for therapeutics to prevent Alzheimer’s disease

Jon Nilsen, Ronald W. Irwin, Rana Masri, Roberta Diaz Brinton

Journal:

Alzheimer's & Dementia

Year:

2005

Language:

english

File:

PDF, 57 KB

english, 2005

49

In vitro model system to predict efficacy of estrogens to prevent versus treat Alzheimer’s disease

Roberta Diaz Brinton, Shuhua Chen

Journal:

Alzheimer's & Dementia

Year:

2005

Language:

english

File:

PDF, 48 KB

english, 2005

50

Estrogen receptor beta selective ligands for prevention of neurodegeneration: From in silico screening to at bench bioanalysis

Liqin Zhao, Roberta Diaz Brinton

Journal:

Alzheimer's & Dementia

Year:

2005

Language:

english

File:

PDF, 48 KB

english, 2005

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